I just read two books with similar themes - people who find themselves despairing over modern life so they pack it all up and move to the wilderness - they both end up along the Yukon River, one in the Yukon Territory and one in Alaska's interior.
I recommend both books to anyone who can relate to their desire. (Be warned though, they don't make coming into the office any easier.)
The titles are Up the Yukon Without A Paddle by Dorian Amos, and Call of the Wild by Guy Grieve. (Another excellent one is Chris Czajkowski's Diary of a Wilderness Dweller.)
Here is a short interview with Grieve: